Effect of intragastric administration on the morphology of laboratory rats’ gastrointestinal tract

BACKGROUND: In preclinical studies on laboratory animals, oral administration with special probe for test substances is very in demand. Most are devoted to the psychophysiological and clinical-biochemical reaction of animals body this effect, but extremely few consider effect manipulation itself development pathology tissues gastrointestinal tract associated inevitable mechanical impact mucous membranes.
 AIM: To identify pathological changes organs rats that effects intragastric tested substances, compare data obtained frequency spontaneous diseases.
 MATERIALS AND METHODS: The pathomorphological observations from Wistar involved course scientific work carried out at NPO Dom Pharmacy period 2018 2021 were used. 1400 sentinel analyzed, same number intact rats. Intact gavaged a control substance (distilled water) 14 days.
 RESULTS: less than 5% clinically healthy inflammatory diseases insignificant intensity prevalence all parts intestine can be detected. As result anipulation administration, an almost twofold increase cases catarrhal esophagitis gastritis, erosive ulcerative lesions membrane esophagus stomach its glandular part hyperkeratosis non-glandular was noted.
 CONCLUSIONS: type occurrence background determined. It has been proven repeated traumatization contact solid metal epithelium provokes stomach, without affecting underlying intestine.